The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 08, 2015

Filed:

Aug. 28, 2014
Applicant:

Genzyme Corporation, Cambridge, MA (US);

Inventors:

Elyse Bourque, Blaine, WA (US);

Bradford Hirth, Framingham, MA (US);

Renato Sklerj, West Newton, MA (US);

Elina Makino, Winchester, MA (US);

Fazeela Morshed, Waltham, MA (US);

Lingyun Li, Waltham, MA (US);

Paul Mason, Natick, MA (US);

John P. Leonard, Manchester, NH (US);

James Lillie, Wellesley, MA (US);

Hanlan Liu, Lexington, MA (US);

Mary A. Cromwell, Groton, MA (US);

Bing Wang, Newton, MA (US);

Thomas O'Shea, Wellesley, MA (US);

Assignee:

Genzyme Corporation, Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/90 (2006.01); A61K 31/44 (2006.01); C07D 453/02 (2006.01); A61K 38/47 (2006.01); A61K 31/439 (2006.01); A61K 31/454 (2006.01); C07D 453/00 (2006.01);
U.S. Cl.
CPC ...
C07D 453/02 (2013.01); A61K 31/439 (2013.01); A61K 31/454 (2013.01); A61K 38/47 (2013.01); C07D 453/00 (2013.01);
Abstract

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.


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