The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9126913 B1

Date of Patent:

Sep. 08, 2015

Filed:

Mar. 13, 2014

Diarylalkanes as potent inhibitors of binuclear enzymes

Applicant:

Unigen, Inc., Seattle, WA (US);

Inventors:

Qi Jia, Olympia, WA (US);

Ji-Fu Zhao, Olympia, WA (US);

Assignee:

Unigen, Inc., Seattle, WA (US);

Attorney:

Seed IP Law Group, PLLC

Primary Examiner:

Craig Ricci

Int. Cl.

CPC ...

A61K 31/075 (2006.01); C07C 43/23 (2006.01); A61K 31/015 (2006.01); A61K 31/05 (2006.01); A61K 31/085 (2006.01); A61K 31/09 (2006.01); A61K 31/357 (2006.01); A61K 31/40 (2006.01); A61K 31/704 (2006.01); C07C 39/15 (2006.01); C07C 39/367 (2006.01); C07C 45/67 (2006.01); C07C 49/835 (2006.01); C07C 215/74 (2006.01); C07D 321/12 (2006.01); A61K 8/34 (2006.01); A61Q 19/02 (2006.01); C07C 41/26 (2006.01); C07C 41/32 (2006.01);

U.S. Cl.

CPC ...

C07C 43/23 (2013.01); A61K 8/347 (2013.01); A61K 31/015 (2013.01); A61K 31/05 (2013.01); A61K 31/085 (2013.01); A61K 31/09 (2013.01); A61K 31/357 (2013.01); A61K 31/40 (2013.01); A61K 31/704 (2013.01); A61Q 19/02 (2013.01); C07C 39/15 (2013.01); C07C 39/367 (2013.01); C07C 41/26 (2013.01); C07C 41/32 (2013.01); C07C 45/673 (2013.01); C07C 49/835 (2013.01); C07C 215/74 (2013.01); C07D 321/12 (2013.01);

Abstract

The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.

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