The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2015
Filed:
Nov. 14, 2011
Synergistic combinations to reduce particle dose for targeted treatment of cancer and its metastases
Patrick J. Sinko, Annandale, NJ (US);
Jieming Gao, New Brunswick, NJ (US);
Manjeet Deshmukh, Edison, NJ (US);
Xiaoping Zhang, Edison, NJ (US);
Matthew S. Palombo, Marmora, NJ (US);
Sherif Ibrahim, Old Bridge, NJ (US);
Patrick J. Sinko, Annandale, NJ (US);
Jieming Gao, New Brunswick, NJ (US);
Manjeet Deshmukh, Edison, NJ (US);
Xiaoping Zhang, Edison, NJ (US);
Matthew S. Palombo, Marmora, NJ (US);
Sherif Ibrahim, Old Bridge, NJ (US);
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);
Abstract
Non-Small Cell Lung Carcinomas (NSCLCs) are treated with Gel Micro-Particles (GMPs) that passively accumulate in the lungs and contain Nano-Particles (NPs) combining one or more therapeutic agents that are cytotoxic to the NSCLC with one or more NSCLC active targeting ligands, as well as one or more other optional agents that increase cellular uptake, enhance the pro-apoptotic effect of the chemotherapeutic agent(s), and the like. NPs targeting other cancer cells are also disclosed, as well as NP-containing GMPs that reduce the occurrence of tumor metastasis.