The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2015
Filed:
Jan. 20, 2011
Applicants:
Rita Slaaby, Lyngby, DK;
Inger Lautrup-larsen, Virum, DK;
Inventors:
Rita Slaaby, Lyngby, DK;
Inger Lautrup-Larsen, Virum, DK;
Assignee:
Novo Nordisk A/S, Bagsvaerd, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/19 (2006.01); C07K 14/50 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/50 (2013.01); A61K 38/00 (2013.01);
Abstract
Expression of FGF21 in apmt2 knock out strain reduces the O-glycosylation significantly and does not decrease the expression level. Expression in mkc7 knock out strain can decrease degradation of FGF21 and analogues thereof. Point mutations at position R17 and R36 can decrease degradation of FGF21 and analogues thereof when they are expressed in yeast.