The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2015
Filed:
Feb. 09, 2011
Karen Cromie, Merelbeke, BE;
Bruno Dombrecht, Heusden, BE;
Seth Ettenberg, Melrose, MA (US);
Joost Kolkman, Sint-Martens-Latem, BE;
Jing LI, Lexington, MA (US);
Kris Meerschaert, Sint-Gillis-Waas, BE;
David Raymond Stover, Sherman Oaks, CA (US);
Jingxin Zhang, Walpole, MA (US);
Karen Cromie, Merelbeke, BE;
Bruno Dombrecht, Heusden, BE;
Seth Ettenberg, Melrose, MA (US);
Joost Kolkman, Sint-Martens-Latem, BE;
Jing Li, Lexington, MA (US);
Kris Meerschaert, Sint-Gillis-Waas, BE;
David Raymond Stover, Sherman Oaks, CA (US);
Jingxin Zhang, Walpole, MA (US);
NOVARTIS AG, Basel, CH;
Abstract
The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also 'DR5'), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as 'NB agents') and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.