The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2015
Filed:
Apr. 18, 2012
Applicants:
Alexei Demchenko, Glen Carbon, IL (US);
Michael R. Nichols, St. Charles, MO (US);
Sophon Kaeothip, Bangkok, TH;
Inventors:
Alexei Demchenko, Glen Carbon, IL (US);
Michael R. Nichols, St. Charles, MO (US);
Sophon Kaeothip, Bangkok, TH;
Assignee:
Curators of the University of Missouri, Columbia, MO (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 15/04 (2006.01); A61K 9/00 (2006.01); A61K 47/06 (2006.01); A61K 47/12 (2006.01); A61K 9/06 (2006.01); A61K 47/32 (2006.01); A61K 47/38 (2006.01); A61K 9/20 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2006.01); A61K 9/48 (2006.01);
U.S. Cl.
CPC ...
C07H 15/04 (2013.01); A61K 9/008 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/06 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 47/06 (2013.01); A61K 47/12 (2013.01); A61K 47/32 (2013.01); A61K 47/38 (2013.01); A61K 9/2027 (2013.01); A61K 9/2059 (2013.01); A61K 9/4858 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01);
Abstract
The invention provides a series of novel Lipid A analogs that are structually simple, synthetically accessible, and capable of blocking the cellular receptor within the signal transduction pathway. The novel Lipid A analogs can include a monosaccharide core with hydrophobic side chains and amino acid ionic motif. The invention further provides methods of using the compounds and compositions thereof in various therapeutic methods.