The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2015
Filed:
Dec. 13, 2012
Nanyang Technological University, Singapore, SG;
Yonggui Chi, Singapore, SG;
Bhoopendra Tiwari, Singapore, SG;
Nanyang Technological University, Singapore, SG;
Abstract
Present invention relates to a method of preparing a chiral α- or β-substituted ketone from the corresponding β- or γ-substituted aldehyde, wherein the ketone has formula (I), (III) or (V), and the corresponding aldehyde has formula (II), (IV) or (VI), respectively, the method comprising reacting the aldehyde of formula (II), (IV) or (VI) in the presence of an amine, oxygen and an organic solvent, wherein the reaction is carried out in the absence of a metal-based catalyst or a metal-based oxidant, wherein: R is H, a substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted C-Ccycloalkyl, substituted or unsubstituted C-Ccycloalkenyl, substituted or unsubstituted C-Cheterocycloalkyl, substituted or unsubstituted C-Cheterocycloalkenyl, substituted or unsubstituted C-Caryl, or substituted or unsubstituted C-Cheteroaryl; and R' is H, a substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted C-Ccycloalkyl, substituted or unsubstituted C-Ccycloalkenyl, substituted or unsubstituted C-Cheterocycloalkyl, substituted or unsubstituted C-Cheterocycloalkenyl, substituted or unsubstituted C-Caryl, or substituted or unsubstituted C-Cheteroaryl.