The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 01, 2015

Filed:

Jul. 17, 2006
Applicants:

Mazen H. Hanna, Bradford, GB;

Peter York, Ilkley, GB;

Inventors:

Mazen H. Hanna, Bradford, GB;

Peter York, Ilkley, GB;

Assignee:

NEKTAR THERAPEUTICS, San Francisco, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 25/00 (2006.01); A23L 1/30 (2006.01); A61K 9/14 (2006.01); A61K 9/00 (2006.01); B01D 9/00 (2006.01); A61K 9/16 (2006.01);
U.S. Cl.
CPC ...
B01D 9/0054 (2013.01); A61K 9/00 (2013.01); A61K 9/14 (2013.01); A61K 9/1694 (2013.01); A61K 9/1652 (2013.01);
Abstract

Embodiments of the invention provide a composition of a particulate coformulation which includes particles containing an active substance and an additive, wherein each particle contains a relative additive concentration increasing radially outwards from a particle center to a particle surface along a finite gradient. In one example, the particle surface is an additive-rich surface without a distinct physical boundary between the particle center and the particle surface. The relative additive concentration may have a continuous rate of change across the finite gradient. In some examples, an active substance: additive ratio of the particle surface is sufficiently low to form a protective surface layer around the active substance. Generally, the particle surface is free of the active substance.


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