The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2015
Filed:
Nov. 29, 2012
Applicant:
Life Technologies As, Carlsbad, CA (US);
Inventors:
Tanja Aarvak, Oslo, NO;
Anne-Marie Rasmussen, Oslo, NO;
Gunnar Kvalheim, Oslo, NO;
Walter Gabriell Borelli Piedras, Montevideo, UY;
Anne Brunsvig, Stabekk, NO;
Assignee:
Life Technologies AS, Oslo, NO;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61K 31/12 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A61K 31/12 (2013.01); C12N 5/0636 (2013.01); C12N 5/0637 (2013.01); C12N 2501/999 (2013.01);
Abstract
Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25− T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.