The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2015
Filed:
Nov. 07, 2012
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Rachel E. Haurwitz, Berkeley, CA (US);
Jennifer A. Doudna, Berkeley, CA (US);
Blake Wiedenheft, Oakland, CA (US);
Martin Jinek, Berkeley, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12P 19/34 (2006.01); C12N 9/22 (2006.01); C07K 14/81 (2006.01); C12Q 1/68 (2006.01); C07K 1/22 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); C07K 1/22 (2013.01); C07K 14/8117 (2013.01); C12P 19/34 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6816 (2013.01); C12Q 1/6823 (2013.01);
Abstract
The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.