The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2015
Filed:
Mar. 09, 2011
Yves Chevalier, Vernaison, FR;
Géraldine Agusti, Villeurbanne, FR;
Coralie Nyffenegger, Fontenay-aux-Roses, FR;
Eric Doelker, Conches, CH;
Olivier Jordan, Prangins, CH;
Gert Andersen, Copenhague, DK;
Yves Chevalier, Vernaison, FR;
Géraldine Agusti, Villeurbanne, FR;
Coralie Nyffenegger, Fontenay-aux-Roses, FR;
Eric Doelker, Conches, CH;
Olivier Jordan, Prangins, CH;
Gert Andersen, Copenhague, DK;
ANTIA THERAPEUTICS S.A., Bern, CH;
UNIVERSITE CLAUDE BERNARD LYON 1, Villeurbanne Cedex, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris Cedex, FR;
Abstract
The invention concerns a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a PVA having covalently grafted thereon iodinated benzyl groups comprising 1-4 iodine atoms per benzyl group, a process for preparing the same comprising reacting a 0-100% hydrolyzed PVA with a iodinated benzyl derivative comprising 1-4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base in anhydrous conditions. Said iodo-benzylether-PVA is particularly useful as embolic agent in an injectable embolizing composition. The invention also concerns an injectable embolizing composition comprising said iodo-benzylether-PVA and capable of forming a cohesive mass upon contact with a body fluid by precipitation of the iodo-benzylether-PVA. Said injectable embolizing composition is particularly useful for forming in-situ a cohesive mass in a blood vessel or into a tumor. The invention further concerns a coating composition containing said iodo-benzylether-PVA and capable of forming a radiopaque coating on a medical device. The invention further concerns particles formed of said iodo-benzylether-PVA.