The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 25, 2015

Filed:

Oct. 25, 2011
Applicants:

MY Hedhammar, Stockholm, SE;

Jan Johansson, Stockholm, SE;

Anna Rising, Uppsala, SE;

Per Åke Nygren, Ekerö, SE;

Inventors:

My Hedhammar, Stockholm, SE;

Jan Johansson, Stockholm, SE;

Anna Rising, Uppsala, SE;

Per Åke Nygren, Ekerö, SE;

Assignee:

SPIBER TECHNOLOGIES AB, Uppsala, SE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/435 (2006.01); A61K 47/48 (2006.01); B01D 15/38 (2006.01); B01J 20/281 (2006.01); C07K 16/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/43518 (2013.01); A61K 47/48169 (2013.01); A61K 47/48369 (2013.01); B01D 15/3804 (2013.01); B01D 15/3809 (2013.01); B01D 15/3823 (2013.01); B01J 20/281 (2013.01); C07K 16/065 (2013.01); C07K 2319/21 (2013.01); C07K 2319/22 (2013.01); C07K 2319/70 (2013.01); C07K 2319/705 (2013.01); C12N 2533/50 (2013.01); Y10S 210/905 (2013.01);
Abstract

A protein structure capable of selective interaction with an organic target is provided. The protein structure is a polymer comprising as a repeating structural unit a recombinant fusion protein that is capable of selective interaction with the organic target. The fusion protein is comprising the moieties B, REP and CT, and optionally NT. B is a non-spidroin moiety of more than 30 amino acid residues, which provides the capacity of selective interaction with the organic target. REP is a moiety of from 70 to 300 amino acid residues and is derived from the repetitive fragment of a spider silk protein. CT is a moiety of from 70 to 120 amino acid residues and is derived from the C-terminal fragment of a spider silk protein. NT is an optional moiety of from 100 to 160 amino acid residues and is derived from the N-terminal fragment of a spider silk protein. The fusion protein and protein structure thereof is useful as an affinity medium and a cell scaffold material.


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