The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2015
Filed:
Oct. 18, 2011
Applicants:
Todd G. Smith, Decatur, GA (US);
Xianfu Wu, Atlanta, GA (US);
Inventors:
Todd G. Smith, Decatur, GA (US);
Xianfu Wu, Atlanta, GA (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01); C12Q 1/00 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
C07K 16/10 (2013.01); G01N 33/56983 (2013.01); C07K 2317/21 (2013.01); C07K 2317/33 (2013.01); C07K 2317/569 (2013.01); C12Q 1/00 (2013.01); G01N 2333/145 (2013.01); G01N 2500/10 (2013.01);
Abstract
Described herein is a method of identifying a monoclonal antibody (or antigen-binding fragment thereof) that specifically binds a plurality of lyssaviruses for use in post-exposure rabies prophylaxis or in the treatment of clinical rabies. The method includes using a naïve antibody phage display library to screen for phage clones that bind whole recombinant rabies virus or cells expressing glycoprotein from multiple lyssaviruses (such as RABV, MOKV and WCBV) and/or specifically bind recombinant glycoprotein from different lyssaviruses.