The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 25, 2015

Filed:

Mar. 08, 2012
Applicants:

York Yuanyuan Zhu, Palo Alto, CA (US);

Tiejun LI, Nantong, CN;

Inventors:

York YuanYuan Zhu, Palo Alto, CA (US);

TieJun Li, Nantong, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); A61K 31/7088 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); A61K 31/7088 (2013.01); C12N 2310/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3519 (2013.01); C12N 2310/52 (2013.01); C12N 2310/53 (2013.01);
Abstract

This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.


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