The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2015
Filed:
Apr. 13, 2012
Wei LV, Shanghai, CN;
Shanbao Yu, Shanghai, CN;
Yu Luo, Shanghai, CN;
Yi Chen, Shanghai, CN;
Jian Ding, Shanghai, CN;
Wei Lv, Shanghai, CN;
Shanbao Yu, Shanghai, CN;
Yu Luo, Shanghai, CN;
Yi Chen, Shanghai, CN;
Jian Ding, Shanghai, CN;
EAST CHINA NORMAL UNIVERSITY, Shanghai, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;
NANJING LUYESIKE PHARMACEUTICAL CO., LTD., Nanjing, CN;
Abstract
Provided are a camptothecin compound containing 7-membered lactone ring, as shown in general formula I, and pharmaceutically acceptable salt thereof, as well as the preparation method and use thereof. In general formula I, Ris H, a C1˜C3 alkyl, acetyl or propionyl; Ris H, a C1˜C6 alkyl, a C3˜C6 cycloalkyl, piperidyl; or a C1˜C6 alkyl substituted by an amino; Ris H, a C1˜C3 alkyl, or a C1˜C6 alkyl substituted by an amino; Ris H, a hydroxyl, or a C1˜C6 alkoxy; Ris H, or a C1˜C6 alkoxyl; or Rand Rare linked to each other to form —OCHO— or —OCHCHO—. The compound has good anti-tumor activity, and can be clinically used via oral administration, intravenous injection, and intramuscular injection, among others.