The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2015
Filed:
Sep. 02, 2014
Asana Biosciences, Llc, Bridgewater, NJ (US);
Roger Astbury Smith, Chester Springs, PA (US);
Scott Kevin Thompson, Phoenixville, PA (US);
Subramanya Hosahalli, Bangalore, IN;
Mallesham Bejugam, Parbhani, IN;
Srinivas Nanduri, Hyderabad, IN;
Sunil Kumar Panigrahi, Kantamal, IN;
Natarajan Mahalingam, Ariyalur, IN;
Asana Biosciences, LLC, Bridgewater, NJ (US);
Abstract
The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.