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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9115065 B1

PDFFull Text
Date of Patent:
Aug. 25, 2015

Filed:

Feb. 26, 2013

Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses

Applicant:

Kineta Four, Llc, Seattle, WA (US);

Inventors:

Dongcheng Dai, Corvallis, OR (US);

Tove Bolken, N. Keizer, OR (US);

Sean M. Amberg, Corvallis, OR (US);

Dennis E. Hruby, Albany, OR (US);

Thomas R. Bailey, Phoenixville, PA (US);

Assignee:

Kineta, Inc., Seattle, WA (US);

Attorneys:

Lee & Hayes, PLLC

C. Rachel Winger

Trevor E. Lind

Primary Examiner:

Golam M M Shameem

Int. Cl.
CPC ...
A61K 31/175 (2006.01); A61K 31/433 (2006.01); C07C 281/06 (2006.01); C07D 285/04 (2006.01); C07C 311/49 (2006.01); A61K 31/18 (2006.01); A61K 31/357 (2006.01); A61K 31/40 (2006.01); A61K 31/415 (2006.01); A61K 31/5377 (2006.01); A61K 31/538 (2006.01); A61K 31/63 (2006.01); A61K 31/42 (2006.01); A61K 31/426 (2006.01); A61K 31/445 (2006.01); A61K 31/496 (2006.01); A61K 31/55 (2006.01); C07D 265/36 (2006.01); C07D 285/06 (2006.01);
U.S. Cl.
CPC ...
C07C 311/49 (2013.01); A61K 31/18 (2013.01); A61K 31/357 (2013.01); A61K 31/40 (2013.01); A61K 31/415 (2013.01); A61K 31/42 (2013.01); A61K 31/426 (2013.01); A61K 31/433 (2013.01); A61K 31/445 (2013.01); A61K 31/496 (2013.01); A61K 31/538 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 31/63 (2013.01); C07D 265/36 (2013.01); C07D 285/06 (2013.01);
Abstract

Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

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