The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2015
Filed:
Mar. 09, 2012
Applicants:
Venu Raman, Ellicott City, MD (US);
Phuoc Tran, Ellicott City, MD (US);
Inventors:
Venu Raman, Ellicott City, MD (US);
Phuoc Tran, Ellicott City, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 41/00 (2006.01); A61K 31/551 (2006.01); A61B 18/18 (2006.01); A61N 5/10 (2006.01); A61K 31/5517 (2006.01);
U.S. Cl.
CPC ...
A61K 41/0038 (2013.01); A61B 18/18 (2013.01); A61K 31/551 (2013.01); A61N 5/10 (2013.01); A61K 31/5517 (2013.01);
Abstract
Provided herein is the compound RK-33, or a salt, solvate, stereoisomer, or derivative thereof, which is shown to be an inhibitor if the DEAD box helicase DDX3, in mammalian cells. RK-33 is also provided herein for use as a radiation dose sensitizer in a subject suffering from a proliferative disease and undergoing radiation therapy. Methods of treatment of proliferative diseases, such as cancer with a combination of RK-33 and radiotherapy methods such as stereotactic ablative radiotherapy (SABR) are also provided.