IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9114138 B1

PDFFull Text
Date of Patent:
Aug. 25, 2015

Filed:

Sep. 12, 2008

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Applicants:

Jose Maria Cid-nunez, Toledo, ES;

Andres Avelino Trabanco-suarez, Toledo, ES;

Gregor James Macdonald, Beerse, BE;

Guillaume Albert Jacques Duvey, Geneva, CH;

Robert Johannes Lutjens, Geneva, CH;

Terry Patrick Finn, Geneva, CH;

Inventors:

Jose Maria Cid-Nunez, Toledo, ES;

Andres Avelino Trabanco-Suarez, Toledo, ES;

Gregor James MacDonald, Beerse, BE;

Guillaume Albert Jacques Duvey, Geneva, CH;

Robert Johannes Lutjens, Geneva, CH;

Terry Patrick Finn, Geneva, CH;

Assignees:

Janssen Pharmaceuticals, Inc., Titusville, NJ (US);

Addex Pharma SA, Geneva, CH;

Attorney:

Baker & Hostetler LLP

Primary Examiner:

David K O Dell

Int. Cl.
CPC ...
C07D 401/04 (2006.01); A61K 31/4545 (2006.01); C07D 493/10 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 211/86 (2006.01); C07D 491/107 (2006.01); A61K 31/444 (2006.01); A61K 9/20 (2006.01); A61K 9/00 (2006.01); A61K 47/10 (2006.01); A61K 9/08 (2006.01); A61K 9/10 (2006.01); A61K 47/44 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4545 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/10 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2018 (2013.01); A61K 9/2059 (2013.01); A61K 31/444 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); A61K 47/44 (2013.01); C07D 211/86 (2013.01); C07D 401/04 (2013.01); C07D 491/107 (2013.01); C07D 493/10 (2013.01);
Abstract

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are as defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors—subtype 2 ('mGluR2') which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

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