The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Nov. 22, 2010
Methods for the identification and treatment of patients sensitive to anti igf-1r inhibition therapy
Sriram Sathyanarayanan, Natick, MA (US);
Christopher Winter, Swampscott, MA (US);
Youyuan Xu, Needham, MA (US);
Sriram Sathyanarayanan, Natick, MA (US);
Christopher Winter, Swampscott, MA (US);
Youyuan Xu, Needham, MA (US);
MERCK SHARP & DOHME CORP., Rahway, NJ (US);
Abstract
The present invention relates to methods for treating a dalotuzumab responsive cancer, in a patient, comprising determining the expression level of liver kinase B1 (LKB1), in a cancer cell from the patient, and when said expression is determined to be lower than that of a control cell; administering, to said patient, a therapeutically effective amount of dalotuzumab. The invention also relates to methods for assessing neoplastic cells, selecting patients, selecting therapies as well as diagnostic methods.