The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 18, 2015

Filed:

Dec. 22, 2006
Applicants:

Adrian Schwartz Mittelman, Winnipeg, CA;

Jeannick Cizeau, Winnipeg, CA;

Nicholas Ronald Glover, Oakville, CA;

Glen Christopher Macdonald, Winnipeg, CA;

Inventors:

Adrian Schwartz Mittelman, Winnipeg, CA;

Jeannick Cizeau, Winnipeg, CA;

Nicholas Ronald Glover, Oakville, CA;

Glen Christopher MacDonald, Winnipeg, CA;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 30/04 (2006.01); C12N 15/10 (2006.01); C07K 16/30 (2006.01); C12P 21/02 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1034 (2013.01); C07K 16/30 (2013.01); C12N 15/1086 (2013.01); C12P 21/02 (2013.01); C40B 30/04 (2013.01); G01N 33/5014 (2013.01); C07K 2316/95 (2013.01); C07K 2317/21 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C07K 2319/55 (2013.01);
Abstract

The invention provides methods for generating fusion protein libraries, such as immunotoxin libraries. The invention also relates to libraries of recombinant cells encoding nucleic acid sequences comprising fusion proteins. In addition, the invention relates to the libraries themselves and the use of the libraries to screen for fusion proteins that are specific for target cells, such as cancer cells. Further, the invention relates to methods of improving fusion proteins and to the improved fusion proteins.


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