The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Dec. 09, 2011
Applicants:
Philippe Despres, La Garenne-Colombes, FR;
Sylvie Paulous, Sarcelles, FR;
Elodie Crublet, L'Albenc, FR;
Inventors:
Philippe Despres, La Garenne-Colombes, FR;
Sylvie Paulous, Sarcelles, FR;
Elodie Crublet, L'Albenc, FR;
Assignee:
INSTITUT PASTEUR, Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/96 (2006.01); C12N 1/20 (2006.01); C12N 1/00 (2006.01); C12N 15/00 (2006.01); C12N 5/07 (2010.01); C12N 9/10 (2006.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 9/96 (2013.01); C12N 9/1007 (2013.01); C12N 15/625 (2013.01); C12N 15/85 (2013.01); C12Y 201/01063 (2013.01); C07K 2319/00 (2013.01); C07K 2319/055 (2013.01); C07K 2319/21 (2013.01);
Abstract
The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.