The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Dec. 10, 2008
Hans Henning Wenk, Muelheim an der Ruhr, DE;
Mike Farwick, Essen, DE;
Sandra Nattland, Essen, DE;
Ursula Maczkiewitz, Essen, DE;
Birgitte Moelholm Malle, Birkeroed, DK;
Hans Henning Wenk, Muelheim an der Ruhr, DE;
Mike Farwick, Essen, DE;
Sandra Nattland, Essen, DE;
Ursula Maczkiewitz, Essen, DE;
Birgitte Moelholm Malle, Birkeroed, DK;
EVONIK GOLDSCHMIDT GMBH, Essen, DE;
NOVOZYMES BIOPOLYMER A/S, Bagsvaerd, DK;
Abstract
The present invention relates to methods of producing crosslinked hyaluronic acid microbeads, as well as the produced microbeads, said method comprising the steps of: (a) providing an aqueous alkaline solution comprising hyaluronic acid, or a salt thereof; (b) forming microdroplets having a desired size from the mixed solution of step (a) in an organic or oil phase to form a water in organic or water in oil (VWO) emulsion, wherein the amount of oil phase used is of from 20 to less than 50% by weight based on the sum of oil phase and water; (c) adding a solution comprising a crosslinking agent to the emulsion, whereby the reaction of hyaluronic acid with the crosslinking agent takes place to provide crosslinked hyaluronic acid microbeads; and (d) optionally working up the dispersion of crosslinked hyaluronic acid microbeads obtained in step (c).