The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Oct. 20, 2009
Applicants:
Robert K. Hickman, Worcester, MA (US);
Ivan R. Correia, Winchester, MA (US);
Inventors:
Robert K. Hickman, Worcester, MA (US);
Ivan R. Correia, Winchester, MA (US);
Assignee:
AbbVie Inc., North Chicago, IL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A23J 1/00 (2006.01); C07K 1/00 (2006.01); C07K 14/16 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 1/36 (2006.01); C07K 1/14 (2006.01); C07K 1/18 (2006.01); C07K 1/16 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C07K 1/36 (2013.01); C07K 1/14 (2013.01); C07K 1/16 (2013.01); C07K 1/18 (2013.01);
Abstract
Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.