The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Jan. 10, 2014
President and Fellows of Harvard College, Cambridge, MA (US);
Tufts University, Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Trustees of Boston University, Boston, MA (US);
Gregory D. Cuny, Somerville, MA (US);
Xin Teng, Framingham, MA (US);
Junying Yuan, Newton, MA (US);
Alexei Degterev, Brookline, MA (US);
John A. Porco, Jr., Brookline, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Tufts University, Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Trustees of Boston University, Boston, MA (US);
Abstract
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.