The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 18, 2015

Filed:

Jul. 19, 2013
Applicant:

The Broad Institute, Inc., Cambridge, MA (US);

Inventors:

Drew Adams, Cambridge, MA (US);

Mingji Dai, West Lafayette, IN (US);

Stuart Schreiber, Boston, MA (US);

Mahmud Mustaqim Hussain, Cambridge, MA (US);

Zarko Boskovic, Cambridge, MA (US);

Assignees:

Howard Hughes Medical Institute, Chevy Chase, MD (US);

The Broad Institute, Cambridge, MA (US);

The President and Fellows of Harvard College, Cambridge, MA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 33/44 (2006.01); C07D 213/62 (2006.01); C07D 213/78 (2006.01); C07D 211/86 (2006.01); C07D 225/02 (2006.01); C07D 211/74 (2006.01); C07D 409/06 (2006.01); C07D 409/04 (2006.01); C07D 401/04 (2006.01); C07D 405/06 (2006.01); C07C 233/91 (2006.01); A61K 31/4412 (2006.01); A61K 31/55 (2006.01); A61K 31/45 (2006.01); A61K 31/4015 (2006.01); A61K 45/06 (2006.01); C07D 223/10 (2006.01); C07D 207/38 (2006.01); A61K 31/4436 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
C07D 211/86 (2013.01); A61K 31/4015 (2013.01); A61K 31/444 (2013.01); A61K 31/4412 (2013.01); A61K 31/4436 (2013.01); A61K 31/45 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07C 233/91 (2013.01); C07D 207/38 (2013.01); C07D 211/74 (2013.01); C07D 223/10 (2013.01); C07D 225/02 (2013.01); C07D 401/04 (2013.01); C07D 405/06 (2013.01); C07D 409/04 (2013.01); C07D 409/06 (2013.01);
Abstract

Compounds including various oligomers of piperlongumine and/or piperlongumine analogues as well as certain piperlongumine analogues that exhibit improved toxicity to cancer cells are disclosed. Also provided are compositions that comprise the compounds, methods of making compositions comprising the compounds, methods of making the compounds, and the use of compounds in methods for treating cancer.


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