The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Nov. 02, 2009
Applicants:
Jia Guo, Pittsford, NY (US);
Xin Lin, Rochester, NY (US);
Steve Georas, Rochester, NY (US);
Patricia Sime, Pittsford, NY (US);
Inventors:
Jia Guo, Pittsford, NY (US);
Xin Lin, Rochester, NY (US);
Steve Georas, Rochester, NY (US);
Patricia Sime, Pittsford, NY (US);
Assignee:
University of Rochester, Rochester, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 45/00 (2006.01); A61K 31/7088 (2006.01); A61K 39/395 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
A61K 45/00 (2013.01); A61K 31/7088 (2013.01); A61K 39/395 (2013.01); A61K 39/39533 (2013.01); A61K 39/39583 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/154 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.