The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Dec. 21, 2012
Applicant:
Taipei Veterans General Hospital, Taipei, TW;
Inventors:
Shih-Hwa Chiou, Taipei, TW;
Guang-Yuh Chiou, Taipei, TW;
Assignee:
Taipei Veterans General Hospital, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); A61K 31/7088 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 31/7088 (2013.01); C12N 15/113 (2013.01); A01K 2267/0331 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/346 (2013.01); C12N 2320/31 (2013.01); C12N 2330/10 (2013.01);
Abstract
The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.