The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Nov. 24, 2010
Peter I. Lelkes, Cherry Hill, NJ (US);
Mengyan LI, Tampa, FL (US);
Anat Perets, Wynnewood, PA (US);
Pimporn Uttayarat, Philadelphia, PA (US);
Robert J. Levy, Merion Station, PA (US);
Russell J. Composto, Philadelphia, PA (US);
Peter I. Lelkes, Cherry Hill, NJ (US);
Mengyan Li, Tampa, FL (US);
Anat Perets, Wynnewood, PA (US);
Pimporn Uttayarat, Philadelphia, PA (US);
Robert J. Levy, Merion Station, PA (US);
Russell J. Composto, Philadelphia, PA (US);
Drexel University, Philadelphia, PA (US);
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.