The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Nov. 10, 2011
Johannes Dapprich, Lawrenceville, NJ (US);
Benjamin Garcia, Princeton, NJ (US);
Gary Leroy, Neptune, NJ (US);
Johannes Dapprich, Lawrenceville, NJ (US);
Benjamin Garcia, Princeton, NJ (US);
Gary Leroy, Neptune, NJ (US);
The Trustees of Princeton University, Princeton, NJ (US);
Generation Biotech, Lawrenceville, NJ (US);
Abstract
An automated protein preparation technology that may use magnetic microparticles to isolate proteins in their native state from specific genomic loci of interest via the chromatin to which they are bound is described. After extraction, the targeted proteins may be purified for downstream analysis by quantitative mass spectrometry or ELISA. The identification of DNA-bound proteins, histones and their post-translational modification is of high scientific and pharmaceutical importance due to the role of DNA-binding proteins in the cauzation and development of human disease; in particular, cancer.