The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 11, 2015

Filed:

Aug. 20, 2013
Applicant:

International Business Machines Corporation, Armonk, NY (US);

Inventors:

Ali Afzali-Ardakani, Ossining, NY (US);

Christopher P. D'Emic, Ossining, NY (US);

Ashish Jagtiani, Irvington, NY (US);

Sufi Zafar, Briarcliff Manor, NY (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01R 27/26 (2006.01); G01F 1/00 (2006.01); G01N 27/26 (2006.01); G01N 27/22 (2006.01); G01N 27/416 (2006.01); G01R 1/00 (2006.01); G06F 3/044 (2006.01); G01N 27/327 (2006.01); G01D 5/24 (2006.01);
U.S. Cl.
CPC ...
G01N 27/221 (2013.01); G01N 27/3276 (2013.01); G01N 27/4167 (2013.01); G01R 1/00 (2013.01); G06F 3/044 (2013.01); G01D 5/24 (2013.01); G01N 27/227 (2013.01); G01R 27/26 (2013.01);
Abstract

A mechanism is provided for determining an isoelectric point of a molecule. A first group of capacitance versus voltage curves of a capacitor is measured. The capacitor includes a substrate, dielectric layer, and conductive solution. The first group of curves is measured for pH values of the solution without the molecule bound to a functionalized material on the dielectric layer of the capacitor. A second group of capacitance versus voltage curves of the capacitor is measured when the molecule is present in the solution, where the molecule is bound to the functionalized material of the dielectric layer of the capacitor. A shift is determined in the second group of curves from the first group of curves at each pH value. The isoelectric point of the molecule is determined by extrapolating a pH value corresponding to a shift voltage being zero, when the shift is compared to the pH values.


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