The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Oct. 02, 2008
Applicant:
David L. Craft, Ft. Thomas, KY (US);
Inventor:
David L. Craft, Ft. Thomas, KY (US);
Assignee:
Cognis IP Management GmbH, Duesseldorf, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/19 (2006.01); C12R 1/74 (2006.01); C12P 7/44 (2006.01);
U.S. Cl.
CPC ...
C12R 1/74 (2013.01); C12P 7/44 (2013.01);
Abstract
Genetically modified strains of, which will not revert to wild-type activity at the POX 4 and/or POX 5 locus, are disclosed. The strains are β-oxidation blocked and have been transformed through homologous recombination with a construct which deletes a portion of the POX 4 and/or POX 5 gene. The modified strains may be used to increase yields of dicarboxylic acids produced in host cells of the strains. Methods for blocking the β-oxidation pathway in ahost cell are also provided.