The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Dec. 12, 2011
Robert Hofmeister, Hingham, MA (US);
Birgit Kohleisen, München, DE;
Ulla Lenkkeri-schütz, Eching, DE;
Christian Itin, Gräfelfing, DE;
Patrick Bäuerle, Gauting, DE;
Francis J. Carr, Balmedie, GB;
Anita A. Hamilton, Aberdeen, GB;
Stephen Williams, Alford, GB;
Robert Hofmeister, Hingham, MA (US);
Birgit Kohleisen, München, DE;
Ulla Lenkkeri-Schütz, Eching, DE;
Christian Itin, Gräfelfing, DE;
Patrick Bäuerle, Gauting, DE;
Francis J. Carr, Balmedie, GB;
Anita A. Hamilton, Aberdeen, GB;
Stephen Williams, Alford, GB;
AMGEN RESEARCH (MUNICH) GMBH, Munich, DE;
Abstract
The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.