The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Mar. 13, 2008
Paul Bruzinski, Clifton Park, NY (US);
Xuejun Liu, Arcadia, CA (US);
Cameron Gibb, Delmar, NY (US);
Pedro E. Hernandez-abad, Arroyo, PR (US);
Paul Bruzinski, Clifton Park, NY (US);
Xuejun Liu, Arcadia, CA (US);
Cameron Gibb, Delmar, NY (US);
Pedro E. HErnandez-Abad, Arroyo, PR (US);
CAN-FITE BIOPHARMA LTD., Petach Tikva, IL;
Abstract
The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.