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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9102631 B1

PDFFull Text
Date of Patent:
Aug. 11, 2015

Filed:

Nov. 01, 2012

1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof

Applicant:

Impact Therapeutics, Inc., Nanjing, Jiangsu, CN;

Inventors:

Suixiong Cai, Jiangsu, CN;

Ye Edward Tian, Jiangsu, CN;

Lizhen Wu, Jiangsu, CN;

Lijun Liu, Jiangsu, CN;

Xiaozhu Wang, Jiangsu, CN;

Yangzhen Jiang, Jiangsu, CN;

Guoxiang Wang, Jiangsu, CN;

Xiuyan Zhang, Jiangsu, CN;

Qingbing Xu, Jiangsu, CN;

Zheng Meng, Jiangsu, CN;

Assignee:

IMPACT Therapeutics, Inc., Nanjing, Jiangsu, CN;

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Brian McDowell

Int. Cl.
CPC ...
C07D 239/96 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); A61K 31/517 (2006.01); C07D 239/90 (2006.01); C07D 487/04 (2006.01); C07D 491/052 (2006.01); C07D 495/04 (2006.01); A61K 45/06 (2006.01); C07D 405/12 (2006.01); C07D 239/70 (2006.01); A61N 5/10 (2006.01); C07D 409/14 (2006.01);
U.S. Cl.
CPC ...
C07D 239/96 (2013.01); A61K 31/517 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); C07D 239/70 (2013.01); C07D 239/90 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 417/12 (2013.01); C07D 487/04 (2013.01); C07D 491/052 (2013.01); C07D 495/04 (2013.01);
Abstract

Disclosed are novel 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs thereof, represented by the Formula 1: wherein Ar, A, R, R-Rare defined herein. Compounds having Formula I are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity, such as cancer.

Find Patent Forward Citations

Cai, Suixiong. (2015). 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof (U.S. Patent No. 9102631). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9102631

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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