The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9102625 B1

Date of Patent:

Aug. 11, 2015

Filed:

Nov. 01, 2011

Nicotinamides as jak kinase modulators

Applicants:

Shawn M. Bauer, Pacifica, CA (US);

Yonghong Song, Foster City, CA (US);

Qing Xu, Foster City, CA (US);

Jack W. Rose, San Mateo, CA (US);

Zhaozhong J. Jia, San Mateo, CA (US);

Brian Kane, Oakland, CA (US);

Wolin Huang, Foster City, CA (US);

Anjali Pandey, Fremont, CA (US);

Mukund Mehrotra, South San Francisco, CA (US);

Inventors:

Shawn M. Bauer, Pacifica, CA (US);

Yonghong Song, Foster City, CA (US);

Qing Xu, Foster City, CA (US);

Jack W. Rose, San Mateo, CA (US);

Zhaozhong J. Jia, San Mateo, CA (US);

Brian Kane, Oakland, CA (US);

Wolin Huang, Foster City, CA (US);

Anjali Pandey, Fremont, CA (US);

Mukund Mehrotra, South San Francisco, CA (US);

Assignee:

PORTOLA PHARMACEUTICALS, INC., South San Francisco, CA (US);

Attorney:

Kilpatrick Townsend & Stockton LLP

Primary Examiner:

Sreeni Padmanabhan

Assistant Examiner:

Irina Neagu

Int. Cl.

CPC ...

C07D 213/82 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); A61K 31/455 (2006.01); A61P 35/00 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01);

U.S. Cl.

CPC ...

C07D 213/82 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01);

Abstract

The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

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