The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Jan. 03, 2012
Victor Reggie Edgerton, Los Angeles, CA (US);
Roland R. Roy, Playa Vista, CA (US);
Yury Gerasimenko, Los Angeles, CA (US);
Joel W. Burdick, Pasadena, CA (US);
Susan J. Harkema, Louisville, KY (US);
Jonathan Hodes, Louisville, KY (US);
Yu-chong Tai, Pasadena, CA (US);
Mandheerej S. Nandra, Pasadena, CA (US);
Claudia A. Angeli, Louisville, KY (US);
Thomas Anthony Desautels, Pasadena, CA (US);
Victor Reggie Edgerton, Los Angeles, CA (US);
Roland R. Roy, Playa Vista, CA (US);
Yury Gerasimenko, Los Angeles, CA (US);
Joel W. Burdick, Pasadena, CA (US);
Susan J. Harkema, Louisville, KY (US);
Jonathan Hodes, Louisville, KY (US);
Yu-Chong Tai, Pasadena, CA (US);
Mandheerej S. Nandra, Pasadena, CA (US);
Claudia A. Angeli, Louisville, KY (US);
Thomas Anthony Desautels, Pasadena, CA (US);
The Regents of the University of California, Oakland, CA (US);
California Institute of Technology, Pasadena, CA (US);
University of Louisville Research Foundation, Inc., Louisville, KY (US);
Abstract
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and/or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and/or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.