The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 11, 2015

Filed:

Jul. 10, 2010
Applicants:

Arnab Basu, Newton Lower Falls, MA (US);

Debra M. Mills, Ayer, MA (US);

Norton P. Peet, North Andover, MA (US);

John D. Williams, Worcester, MA (US);

Inventors:

Arnab Basu, Newton Lower Falls, MA (US);

Debra M. Mills, Ayer, MA (US);

Norton P. Peet, North Andover, MA (US);

John D. Williams, Worcester, MA (US);

Assignee:

MICROBIOTIX, INC., Worcester, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/18 (2006.01); A61K 31/5513 (2006.01); C07D 213/74 (2006.01); C07D 215/40 (2006.01); C07D 243/12 (2006.01); C07D 249/10 (2006.01); C07D 307/71 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/04 (2006.01); C07D 471/04 (2006.01); C07D 491/22 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5513 (2013.01); A61K 31/18 (2013.01); C07D 213/74 (2013.01); C07D 215/40 (2013.01); C07D 243/12 (2013.01); C07D 249/10 (2013.01); C07D 307/71 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 471/04 (2013.01); C07D 491/22 (2013.01);
Abstract

Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filovirus including the type species Marburg virus (MARV) and Ebola virus (EBOV). Preferred inhibitors of the invention provide therapeutic agents for combating the Ivory Coast, Sudan, Zaire, Bundibugyo, and Reston Ebola virus strains.


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