The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9101548 B1

PDF
Full Text
Expired
Date of Patent:
Aug. 11, 2015

Filed:

Oct. 24, 2008
Applicants:

Susan Marie Metcalfe, Cambridge, GB;

Tarek M. Fahmy, New Haven, CT (US);

Inventors:

Susan Marie Metcalfe, Cambridge, GB;

Tarek M. Fahmy, New Haven, CT (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 38/19 (2006.01); A61K 39/395 (2006.01); A61K 9/51 (2006.01); A61K 9/127 (2006.01); A61K 47/48 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 9/5153 (2013.01); A61K 9/127 (2013.01); A61K 47/48823 (2013.01); A61K 47/48869 (2013.01); B82Y 5/00 (2013.01);
Abstract

A composition for modulating the immune response in a mammal comprising a pharmaceutically acceptable carrier solution and a plurality of biodegradable nanoparticles, wherein the nanoparticles comprise a targeting moiety that is able to bind selectively to the surface of a T lymphocyte cell and/or of a vascular endothelial cell and wherein the nanoparticles further comprise leukaemia inhibitory factor (LIF). Nanoparticle-mediated targeted delivery of LIF can be used a means to guide tolerogenesis in a patient and has immediate clinical application for recipients of organ grafts and also for patients suffering from autoimmune disease.


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Metcalfe, Susan. (2015). Immuno-modulatory composition (U.S. Patent No. 9101548). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9101548

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