The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2015
Filed:
Jul. 30, 2012
Yu Qian, Hong Kong, HK;
LI Juan Zhang, Hong Kong, HK;
Zhi Min Wu, Hong Kong, HK;
LI Ying Zhou, Hong Kong, HK;
Wei Jiang, Hong Kong, HK;
LI Ling, Hong Kong, HK;
Qian Luo, Hong Kong, HK;
Xin Dong Guo, Hong Kong, HK;
Yu Qian, Hong Kong, HK;
Li Juan Zhang, Hong Kong, HK;
Zhi Min Wu, Hong Kong, HK;
Li Ying Zhou, Hong Kong, HK;
Wei Jiang, Hong Kong, HK;
Li Ling, Hong Kong, HK;
Qian Luo, Hong Kong, HK;
Xin Dong Guo, Hong Kong, HK;
NANO AND ADVANCED MATERIALS INSTITUTE LIMITED, Hong Kong, HK;
Abstract
The invention relates to an enteric-coated capsule containing cationic nanoparticles for oral insulin delivery, in particular to a type of cationic nanoparticle including a polycationic and mucoadhesive polymer and a biodegradable polymer, wherein each of the nanoparticles has positive surface charge and enhanced permeability for paracellular insulin delivery; the enteric-coated capsule further includes a pH-sensitive polymer as the coating. The enteric-coated capsule containing cationic nanoparticles, when being orally administered to a subject, are configured to prevent the acidic degradation of the active substance such as insulin before being released from said cationic nanoparticles to a specific absorption site along the gastrointestinal tract.