The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
May. 12, 2014
Applicant:
Ucb Pharma, S.a., Brussels, BE;
Inventors:
Bryan John Smith, Slough, GB;
Helen Marie Kirke, Slough, GB;
Assignee:
UCB PHARMA, S.A., Brussels, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/37 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); G01N 33/6857 (2013.01); G01N 2333/96433 (2013.01);
Abstract
A method of measuring acidic species generated by degradation of a Fab or Fab' component of a Fab-PEG or a Fab′-PEG is provided. The method involves: a) cleaving PEG and a linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker from the Fab or Fab′ to provide isolated Fab or Fab′; and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab′ and/or the cleaved PEG.