The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
Dec. 23, 2013
Applicants:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Genus Oncology, Llc, Vernon Hills, IL (US);
Inventors:
Donald W. Kufe, Wellesley, MA (US);
Surender Kharbanda, Natick, MA (US);
Assignees:
Genus Oncology, LLC, Chicago, IL (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2006.01); A61K 38/00 (2006.01); A61P 29/00 (2006.01); C07K 14/705 (2006.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); A61K 38/177 (2013.01); A61K 38/1735 (2013.01); A61K 45/06 (2013.01); C07K 14/4727 (2013.01); C07K 2319/10 (2013.01); C07K 2319/23 (2013.01); C07K 2319/50 (2013.01);
Abstract
The invention provides for peptides from the MUC1 cytoplasmic domain and methods of use therefor. These peptides can inhibit MUC1 oligomerization, inhibit the interaction of MUC1 with NF-κB or a STAT, and block inflammatory response mediated by NF-κB or STAT signaling.