The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2015

Filed:

Oct. 02, 2013
Applicant:

Aveo Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

William M. Winston, Jr., Marlborough, MA (US);

S. Kirk Wright, Waltham, MA (US);

May Han, Brookline, MA (US);

Lyne Breault, Roslindale, MA (US);

Jie Lin, West Roxbury, MA (US);

Bijan Etemad-Gilbertson, Jamaica Plain, MA (US);

Christine Knuehl, Natick, MA (US);

Jeno Gyuris, Lincoln, MA (US);

Arnold Horwitz, San Leandro, CA (US);

Assignees:

AVEO Pharmaceuticals, Inc., Cambridge, MA (US);

Xoma Technologies, Ltd., Berkeley, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/63 (2006.01); C12N 5/12 (2006.01); C12N 15/00 (2006.01); C07K 16/22 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.


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