The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
Nov. 15, 2011
Ehud Gazit, Ramat-HaSharon, IL;
Yaniv Amir, Yahud, IL;
Ludmila Buzhansky, Ariel, IL;
Ulrich Abel, Bad Homburg, DE;
Anat Frydman-marom, Tel-Aviv, IL;
Ehud Gazit, Ramat-HaSharon, IL;
Yaniv Amir, Yahud, IL;
Ludmila Buzhansky, Ariel, IL;
Ulrich Abel, Bad Homburg, DE;
Anat Frydman-Marom, Tel-Aviv, IL;
Ramot at Tel-Aviv University Ltd., Tel-Aviv, IL;
Abstract
Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipeptide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.