The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
Dec. 21, 2011
Pottayil G. N. Sasikumar, Bangalore, IN;
Muralidhara Ramachandra, Bangalore, IN;
Suresh Kumar Vadlamani, Bangalore, IN;
K. Rajeev Shrimali, Hyderabad, IN;
Krishnaprasad Subbarao, Bangalore, IN;
Pottayil G. N. Sasikumar, Bangalore, IN;
Muralidhara Ramachandra, Bangalore, IN;
Suresh Kumar Vadlamani, Bangalore, IN;
K. Rajeev Shrimali, Hyderabad, IN;
Krishnaprasad Subbarao, Bangalore, IN;
Aurigene Discovery Technologies Limited, Bangalore, IN;
Abstract
The present invention provides Immunosuppressive compounds capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signalling induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient. Further, the invention provides pharmaceutical compositions comprising the Immunosuppressive peptide compounds or modified peptide moieties for preventive and/or therapeutic agents for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.