The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
May. 16, 2014
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Mark I. Greene, Penn Valley, PA (US);
Ramachandran Murali, Beverly Hills, CA (US);
Xin Cheng, Wallingford, PA (US);
Raphael Ottenbrite, Midlothian, VA (US);
Yingxin Xiao, North Potomac, MD (US);
Assignee:
The Trustees Of The University Of Pennsylvania, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/15 (2006.01); C07D 311/82 (2006.01); C07D 493/10 (2006.01); C07C 251/86 (2006.01); A61K 31/352 (2006.01); A61K 31/365 (2006.01);
U.S. Cl.
CPC ...
C07D 493/10 (2013.01); A61K 31/15 (2013.01); A61K 31/352 (2013.01); A61K 31/365 (2013.01); C07C 251/86 (2013.01); C07D 311/82 (2013.01);
Abstract
The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-α mediated conditions.