The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
Oct. 11, 2013
The Broad Institute, Inc., Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Florence Fevrier Wagner, Ashland, MA (US);
Jennifer Q. Pan, Acton, MA (US);
Sivaraman Dandapani, Malden, MA (US);
Andrew Germain, Somerville, MA (US);
Edward Holson, Newton, MA (US);
Benito Munoz, Newtonville, MA (US);
Partha P. Nag, Somerville, MA (US);
Michel Weiwer, Cambridge, MA (US);
Michael C. Lewis, Boston, MA (US);
Stephen J. Haggarty, Gloucester, MA (US);
Joshua A. Bishop, Southborough, MA (US);
Kimberly Stegmaier, Jamaica Plain, MA (US);
Versha Banerji, Winnipeg, CA;
The Broad Institute, Inc., Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer.