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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9096571 B1

PDFFull Text
Date of Patent:
Aug. 04, 2015

Filed:

May. 04, 2011

Picolinamide and pyrimidine-4-carboxamide compounds, process for preparing and pharmaceutical composition comprising the same

Applicants:

Je Ho Ryu, Seoul, KR;

Shin AE Kim, Suwon-si, KR;

Keun Ho Ryu, Seoul, KR;

Jae Sun Kim, Suwon-si, KR;

Nam Ho Kim, Yongin-si, KR;

Hye Young Han, Seoul, KR;

Yong Hyuk Kim, Suwon-si, KR;

Won-no Youn, Seoul, KR;

Yoon-jung Lee, Yongin-si, KR;

Hyun Joo Son, Seoul, KR;

Bong-yong Lee, Seoul, KR;

Sung Hoon Park, Seoul, KR;

Ju Young Lee, Suwon-si, KR;

Hyun Jung Lee, Seoul, KR;

Hoe Chul Jung, Seoul, KR;

Young Ah Shin, Yongin-si, KR;

Jung a Lee, Uiwang-si, KR;

BO Ram Lee, Seoul, KR;

Joon Ho SA, Seoul, KR;

Inventors:

Je Ho Ryu, Seoul, KR;

Shin Ae Kim, Suwon-si, KR;

Keun Ho Ryu, Seoul, KR;

Jae Sun Kim, Suwon-si, KR;

Nam Ho Kim, Yongin-si, KR;

Hye Young Han, Seoul, KR;

Yong Hyuk Kim, Suwon-si, KR;

Won-No Youn, Seoul, KR;

Yoon-Jung Lee, Yongin-si, KR;

Hyun Joo Son, Seoul, KR;

Bong-Yong Lee, Seoul, KR;

Sung Hoon Park, Seoul, KR;

Ju Young Lee, Suwon-si, KR;

Hyun Jung Lee, Seoul, KR;

Hoe Chul Jung, Seoul, KR;

Young Ah Shin, Yongin-si, KR;

Jung A Lee, Uiwang-si, KR;

Bo Ram Lee, Seoul, KR;

Joon Ho Sa, Seoul, KR;

Assignee:

SK CHEMICALS CO., LTD., Suwon, KR;

Attorney:

Lowe Hauptman & Ham, LLP

Primary Examiner:

James O Wilson

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 31/55 (2006.01); A61K 31/445 (2006.01); A61K 31/497 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 213/81 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 239/557 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); C07D 213/81 (2013.01); C07D 239/557 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01);
Abstract

Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.

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