The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2015

Filed:

Apr. 13, 2012
Applicants:

Edward Borowski, Gdansk, PL;

Barbara Stefanska, Warsaw, PL;

Maria Dzieduszycka, Sopot, PL;

Marcin Cybulski, Warsaw, PL;

Wieslaw Szelejewski, Warsaw, PL;

Janusz Obukowicz, Stare Babice, PL;

Maria Bontemps-gracz, Gdansk, PL;

Malgorzata Wysocka, Gdansk, PL;

Jan Mazerski, Gdansk, PL;

Pawel Punda, Szczytno, PL;

Joanna Wietrzyk, Wroclaw, PL;

Inventors:

Edward Borowski, Gdansk, PL;

Barbara Stefanska, Warsaw, PL;

Maria Dzieduszycka, Sopot, PL;

Marcin Cybulski, Warsaw, PL;

Wieslaw Szelejewski, Warsaw, PL;

Janusz Obukowicz, Stare Babice, PL;

Maria Bontemps-Gracz, Gdansk, PL;

Malgorzata Wysocka, Gdansk, PL;

Jan Mazerski, Gdansk, PL;

Pawel Punda, Szczytno, PL;

Joanna Wietrzyk, Wroclaw, PL;

Assignee:

BS-154 S.P. ZO.O., Gdansk, PL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 237/26 (2006.01); C07D 487/06 (2006.01); A61K 31/502 (2006.01); A61K 31/5025 (2006.01); C07D 237/36 (2006.01);
U.S. Cl.
CPC ...
C07D 237/26 (2013.01); A61K 31/502 (2013.01); A61K 31/5025 (2013.01); C07D 237/36 (2013.01); C07D 487/06 (2013.01);
Abstract

The invention relates to the new, asymmetrically substituted derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione and their use as cytostatics exhibiting activity against tumor cells, especially against cells with multidrug resistance (MDR). In particular, the invention concerns derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione represented by the general formula (I).


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