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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9096527 B1

PDFFull Text
Date of Patent:
Aug. 04, 2015

Filed:

Feb. 24, 2014

Trpm8 antagonists and their use in treatments

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Kaustav Biswas, Agoura Hills, CA (US);

James Brown, Moorpark, CA (US);

Jian J. Chen, Camarillo, CA (US);

Vijay Keshav Gore, Aliso Veijo, CA (US);

Scott Harried, Pittsburgh, PA (US);

Daniel B. Horne, Simi Valley, CA (US);

Matthew R. Kaller, Ventura, CA (US);

Qingyian Liu, Camarillo, CA (US);

Vu Van Ma, Oak Park, CA (US);

Holger Monenschein, San Diego, CA (US);

Thomas T. Nguyen, Newbury Park, CA (US);

David J. St. Jean, Jr., Camarillo, CA (US);

Chester Chenguang Yuan, Newbury Park, CA (US);

Wenge Zhong, Thousand Oaks, CA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:

Bernard P. Friedrichsen

Primary Examiner:

Savitha Rao

Int. Cl.
CPC ...
C07D 498/04 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 213/40 (2006.01); C07D 213/61 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 213/82 (2013.01); C07D 213/40 (2013.01); C07D 213/61 (2013.01); C07D 213/81 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01);
Abstract

Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

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